Progesterone Cream

Product Overview

Progesterone Cream is a topical (skin-applied) hormone preparation designed to deliver micronised progesterone through the skin into the bloodstream. Progesterone is a naturally occurring hormone produced by the ovaries and plays an essential role in regulating the menstrual cycle, supporting early pregnancy, and balancing estrogen levels.

Progesterone cream may be prescribed for:

• Hormonal imbalance
• Perimenopause and menopause symptom support
• PMS (Premenstrual Syndrome)
• Irregular menstrual cycles
• Luteal phase support in certain cases
• Support alongside estrogen therapy to protect the uterine lining

At Angel Pharmacy, progesterone cream is supplied as a 30g tube, prepared or dispensed strictly according to your doctor’s prescription.

How Progesterone Cream Works

Progesterone applied to the skin is absorbed into the bloodstream. Once absorbed, it:

• Helps balance the effects of estrogen
• Supports healthy menstrual cycles
• Assists in maintaining the uterine lining
• May help reduce symptoms such as hot flushes, mood changes, and sleep disturbance
• Supports hormonal stability during perimenopause and menopause

Unlike oral progesterone, topical progesterone bypasses first-pass liver metabolism, which may reduce some systemic side effects.

Directions for Use

Progesterone cream should be used exactly as prescribed by your healthcare provider.

Typical instructions may include:

• Apply a measured amount once or twice daily
• Apply to clean, dry skin
• Rotate application sites (inner arms, thighs, lower abdomen, or wrists)
• Avoid applying to broken or irritated skin

Wash hands after application unless hands are the treatment area.

Do not exceed the prescribed dose.

Important Safety Information

Before using progesterone cream, inform your doctor if you have:

• A history of breast, uterine, or ovarian cancer
• Blood clotting disorders
• Liver disease
• Heart disease or previous stroke
• Unexplained vaginal bleeding
• Severe migraines
• Depression
• Diabetes

Hormone therapy may increase the risk of blood clots in certain individuals. Women over 35 who smoke should consult their doctor carefully before using hormonal treatments.

Progesterone cream should only be used under medical supervision.

Possible Side Effects

Some individuals may experience:

• Breast tenderness
• Irregular spotting or breakthrough bleeding
• Headache
• Mood changes
• Mild fluid retention
• Drowsiness or fatigue
• Skin irritation at the application site

Seek immediate medical attention if you experience:

• Sudden chest pain
• Shortness of breath
• Severe headache
• Vision changes
• Signs of allergic reaction

Drug Interactions

Progesterone may interact with certain medications, including:

• Anti-seizure medicines (e.g., carbamazepine, phenytoin)
• Rifampin
• Some antifungal medicines
• Herbal supplements such as St. John’s Wort

Always inform your pharmacist and doctor about all medications, supplements, and herbal products you are using.

Pregnancy & Breastfeeding

Progesterone may be prescribed in early pregnancy under specialist supervision, particularly for fertility support. Do not use during pregnancy unless directed by your doctor.

Progesterone is generally considered compatible with breastfeeding; however, medical advice should always be sought before use.

Storage Instructions

• Store below 25°C
• Keep away from heat and direct sunlight
• Do not freeze
• Keep out of reach of children
• Do not use after the expiry date

Frequently Asked Questions

Is progesterone cream the same as oral progesterone?

Both contain progesterone, but the cream is absorbed through the skin, while capsules are taken orally. Absorption and dosing differ.

How long does it take to see results?

Symptom improvement may take several weeks. Hormone therapy should be reviewed regularly by your doctor.

Where should I apply the cream?

Apply to areas with thinner skin and rotate sites daily to improve absorption.

Can I apply it to the breasts?

Only apply to areas directed by your healthcare provider.

Can progesterone cream cause weight gain?

Some individuals may experience mild fluid retention, but significant weight gain is uncommon when used appropriately.

Disclaimer

This information is for educational purposes only and does not replace professional medical advice. Progesterone cream should only be used under the supervision of a qualified healthcare provider.

For personalised advice, speak with our pharmacists at Angel Pharmacy.