Pregnenolone Cream

Product Overview

Pregnenolone Cream is a compounded transdermal hormone preparation designed to support hormone balance under medical supervision.

Pregnenolone is a naturally occurring hormone produced primarily in the adrenal glands and serves as a precursor to several important hormones, including:

• Progesterone
• DHEA
• Estrogen
• Testosterone
• Cortisol

At Angel Pharmacy, Pregnenolone Cream is compounded in personalised strengths and supplied in a 30g tube according to your doctor’s prescription.

Pregnenolone therapy should only be used under the guidance of a qualified healthcare professional.

What Pregnenolone Cream May Be Used For

Pregnenolone Cream may be prescribed as part of a hormone support plan for:

• Adrenal support
• Hormone precursor supplementation
• Fatigue management
• Cognitive support
• Mood balance
• Perimenopause or menopause support
• Integrative hormone optimisation protocols

Treatment is individualised based on symptoms, clinical history, and hormone testing.

How Pregnenolone Cream Works

Pregnenolone acts as a “parent hormone,” meaning it is converted in the body into other steroid hormones.

When applied transdermally (through the skin), pregnenolone:

• Is absorbed into the bloodstream
• Enters hormone pathways
• May influence downstream hormone production

Because hormone pathways are interconnected, dosing must be carefully monitored to avoid imbalance.

Why Use a Transdermal Cream?

Transdermal delivery may offer:

• Steady hormone absorption
• Bypassing first-pass liver metabolism
• Flexible dose adjustments
• Individualised compounding strengths

Your prescriber will determine the most appropriate dose and application site.

Directions for Use

Use exactly as prescribed by your doctor.

General guidance:

• Apply to clean, dry skin
• Common areas include inner arms, thighs, or as directed
• Rotate application sites if advised
• Wash hands after application
• Allow cream to fully absorb before dressing

Do not apply to broken or irritated skin.

Do not adjust your dose without medical advice.

Important Safety Information

Before starting Pregnenolone Cream, inform your doctor if you have:

• Hormone-sensitive conditions
• Breast, ovarian, uterine, or prostate cancer history
• Thyroid disorders
• Liver disease
• Mood disorders
• Cardiovascular conditions

Hormonal therapies require ongoing supervision and monitoring.

Possible Side Effects

Side effects depend on dose and individual hormone response.

Potential side effects may include:

• Headache
• Insomnia
• Mood changes
• Acne or skin changes
• Increased body hair (in some individuals)
• Menstrual irregularities

If symptoms persist or worsen, consult your healthcare provider.

Monitoring & Follow-Up

Your doctor may recommend:

• Baseline hormone testing
• Follow-up blood or saliva hormone levels
• Symptom review
• Dose adjustments based on response

Regular review helps maintain safe and effective therapy.

Pregnancy & Breastfeeding

Pregnenolone Cream should not be used during pregnancy or breastfeeding unless specifically prescribed and closely supervised.

Always inform your healthcare provider if you are pregnant, planning pregnancy, or breastfeeding.

Drug Interactions

Pregnenolone may interact with:

• Hormone replacement therapies
• Corticosteroids
• Thyroid medications
• Other endocrine treatments

Always provide a full list of medications and supplements to your healthcare provider.

Storage Instructions

• Store below 25°C
• Protect from heat and direct sunlight
• Keep tube tightly closed
• Keep out of reach of children
• Do not use after expiry date

Frequently Asked Questions

Is Pregnenolone the same as progesterone?

No. Pregnenolone is a precursor hormone that can be converted into progesterone and other hormones in the body.

How long does it take to notice results?

Response varies. Some individuals notice changes within weeks, while others require longer-term monitoring.

Can I use this alongside other hormone creams?

Only under medical supervision to avoid hormonal imbalance.

Is compounded hormone cream safe?

When prepared by a licensed compounding pharmacy and used as prescribed, it is prepared according to strict quality standards.

Disclaimer

This information is provided for educational purposes only and does not replace professional medical advice. Pregnenolone Cream should only be used under the supervision of a qualified healthcare professional.

For personalised advice regarding your prescription, speak with the pharmacists at Angel Pharmacy.