Clomiphene Citrate

Product Overview

Clomiphene Citrate is a prescription medication commonly used to support ovulation in women experiencing fertility challenges. It belongs to a class of medicines known as selective estrogen receptor modulators (SERMs).

Clomiphene is most frequently prescribed for:

• Ovulation induction
• Polycystic Ovary Syndrome (PCOS)
• Unexplained infertility
• Certain hormone-related reproductive conditions

Clomiphene Citrate Tablets are supplied as commercially manufactured products in accordance with your doctor’s prescription.

What Clomiphene Citrate Is Used For

Ovulation Induction

Clomiphene is widely used to:

• Stimulate ovulation
• Regulate menstrual cycles
• Improve chances of conception
• Support fertility treatment plans

It is often a first-line treatment for women who are not ovulating regularly.

Polycystic Ovary Syndrome (PCOS)

In women with PCOS, Clomiphene may help:

• Trigger ovulation
• Improve cycle predictability
• Increase fertility potential

Treatment is typically monitored with ultrasound and/or blood tests.

Male Hormone Support (Specialist Use)

In some cases, Clomiphene may be prescribed off-label in men to:

• Stimulate natural testosterone production
• Support fertility

This use is determined by a specialist.

How Clomiphene Works

Clomiphene works by blocking estrogen receptors in the hypothalamus. This action:

• Stimulates release of gonadotropin-releasing hormone (GnRH)
• Increases luteinising hormone (LH) and follicle-stimulating hormone (FSH)
• Promotes ovarian follicle development
• Triggers ovulation

It essentially encourages the body to produce the hormones needed for ovulation.

Directions for Use

Take exactly as prescribed by your doctor.

General guidance (for ovulation induction):

• Usually taken once daily for 5 days
• Often started early in the menstrual cycle (e.g., Day 2–5)
• Swallow tablet with water
• Follow your doctor’s cycle instructions carefully

Your healthcare provider will advise on timing of intercourse or additional fertility support.

Do not exceed the prescribed dose.

Important Safety Information

Before starting Clomiphene, inform your doctor if you have:

• Liver disease
• Ovarian cysts (not related to PCOS)
• Unexplained uterine bleeding
• Thyroid disorders
• Adrenal disorders
• Hormone-sensitive conditions

Clomiphene should only be used under medical supervision.

Possible Side Effects

Common side effects may include:

• Hot flushes
• Mood swings
• Breast tenderness
• Nausea
• Headache
• Bloating

Less common but important risks:

• Ovarian enlargement
• Ovarian hyperstimulation syndrome (OHSS)
• Visual disturbances
• Multiple pregnancy (e.g., twins)

Seek medical attention if you experience severe abdominal pain, rapid weight gain, vision changes, or breathing difficulty.

Monitoring & Follow-Up

Your doctor may recommend:

• Ultrasound monitoring of ovarian follicles
• Blood hormone testing
• Ovulation tracking
• Cycle monitoring

Monitoring helps optimise effectiveness and reduce risk.

Fertility & Pregnancy

Clomiphene is used to assist conception but should not be taken once pregnancy is confirmed.

If you suspect pregnancy, contact your healthcare provider immediately.

It is not recommended during breastfeeding.

Drug Interactions

Clomiphene may interact with:

• Hormone therapies
• Fertility medications
• Thyroid medications

Always inform your doctor of all medications and supplements you are taking.

Storage Instructions

• Store below 25°C
• Keep in original packaging
• Protect from moisture
• Keep out of reach of children
• Do not use after expiry date

Frequently Asked Questions

How long does it take to work?

Ovulation typically occurs within the treatment cycle if the medication is effective.

How many cycles can I use Clomiphene?

Treatment duration varies. Many doctors reassess after 3–6 cycles.

Does Clomiphene increase the chance of twins?

Yes, there is a slightly increased chance of multiple pregnancy compared to natural conception.

Will I need monitoring?

Yes. Medical monitoring is recommended to ensure safe and effective treatment.

Is Clomiphene the same as Enclomiphene?

Clomiphene contains two isomers, including enclomiphene. They are related but not identical treatments.

Disclaimer

This information is provided for educational purposes only and does not replace professional medical advice. Clomiphene Citrate should only be used under the supervision of a qualified healthcare professional.

For personalised advice regarding your prescription, speak with the pharmacists at Angel Pharmacy.