Cholecalciferol Injection

Product Overview

Cholecalciferol Injection is a prescription injectable formulation of Vitamin D3, a fat-soluble vitamin essential for calcium and phosphate homeostasis, bone health, immune function, and cellular regulation. This formulation is solubilized in grapeseed oil to enhance absorption and bioavailability.

Vitamin D3 is critical for promoting calcium absorption in the gut, maintaining serum calcium and phosphate levels, supporting bone mineralization, and modulating immune responses. Injectable administration ensures rapid systemic availability, especially in patients with malabsorption, gastrointestinal disorders, or high-dose therapeutic requirements.

This medication is available by prescription only and must be administered under licensed healthcare supervision.

Dosage & Administration

General Dosing Information

Dosing of Cholecalciferol Injection is individualized based on the patient’s vitamin D status, clinical condition, and therapeutic goals.

Typical Adult Use (Examples)

• Administered intramuscularly (IM) or intravenously (IV)
• Dose and frequency depend on baseline vitamin D levels, clinical indication, and patient response
• Commonly used for vitamin D deficiency, osteoporosis support, immune support, and metabolic wellness protocols

Administration Details

• Supplied as a sterile injectable solution in grapeseed oil
• Inspect solution prior to use; do not use if cloudy, discolored, or containing particulate matter
• Use aseptic technique during preparation and administration
• Rotate injection sites for IM use to minimize irritation
• Dispose of needles and syringes in approved sharps containers

Patients should not self-administer unless properly trained and authorized by their healthcare provider.

Treatment Duration & Monitoring

Treatment duration depends on the patient’s vitamin D status and clinical needs:

• Short-term supplementation for acute deficiency
• Maintenance therapy for chronic insufficiency or osteoporosis support

Monitoring may include:

• Serum 25-hydroxyvitamin D levels
• Calcium and phosphate levels
• Observation for injection-site reactions or intolerance

Therapy should be adjusted based on patient response and healthcare provider evaluation.

Mechanism of Action

Cholecalciferol Injection (Vitamin D3) supports multiple physiological processes:

• Promotes calcium and phosphate absorption in the intestine
• Regulates bone mineralization and skeletal health
• Modulates immune function and cellular signaling
• Supports muscle function and cardiovascular health
• Grapeseed oil solubilization enhances bioavailability and systemic delivery

Injectable delivery ensures rapid and reliable systemic absorption, particularly in deficiency or high-demand states.

Contraindications & Precautions

Cholecalciferol Injection should be used with caution or avoided in patients with:

• Known hypersensitivity to vitamin D3 or any component of the formulation, including grapeseed oil
• Hypercalcemia or vitamin D toxicity
• Severe renal impairment without monitoring
• Granulomatous diseases (e.g., sarcoidosis) that may increase vitamin D sensitivity

This product is intended for medically supervised use only. Patients should be evaluated by a licensed healthcare professional prior to therapy initiation.

Drug Interactions

Patients should inform their healthcare provider of all medications and supplements. Vitamin D3 may interact with:

• Thiazide diuretics (may increase risk of hypercalcemia)
• Digoxin (risk of arrhythmias if hypercalcemia occurs)
• Certain anticonvulsants or corticosteroids (may affect vitamin D metabolism)

Clinical judgment should guide concurrent therapy.

Adverse Reactions & Side Effects

Common

• Mild injection-site discomfort
• Redness or swelling at injection site

Less Common

• Nausea or gastrointestinal upset
• Headache
• Hypercalcemia with prolonged or excessive dosing
• Rare hypersensitivity reactions

Adverse effects are generally mild and transient. Seek medical attention for persistent or severe symptoms.

Pregnancy & Breastfeeding

Vitamin D3 is essential during pregnancy and lactation. Injectable supplementation should be used only when medically indicated and under supervision of a licensed healthcare provider. Patients should consult their provider before use.

Storage & Handling

• Store according to Angel Pharmacy compounding and dispensing guidelines
• Typically stored at controlled room temperature or refrigerated as directed
• Protect from light
• Do not freeze
• Keep out of reach of children and pets

Unused or expired medication should be disposed of according to pharmacy or healthcare facility protocols.

Important Notice

This information is provided for educational purposes only and does not replace professional medical advice. All dosing, administration, and treatment decisions must follow the instructions of the prescribing healthcare provider.