DHEA (Dehydroepiandrosterone) and Pregnenolone

Product Overview

DHEA (Dehydroepiandrosterone) and Pregnenolone are naturally occurring adrenal hormones that play an important role in the body’s hormone production pathway.

Pregnenolone is often referred to as the “mother hormone” because it is a precursor to many other hormones, including:

• DHEA
• Progesterone
• Estrogen
• Testosterone
• Cortisol

DHEA further converts into estrogen and testosterone, supporting hormonal balance, energy, and overall wellbeing.

The combined DHEA 50mg / Pregnenolone 100mg capsule is a compounded formulation prescribed by healthcare practitioners to support adrenal function, hormone balance, and age-related hormone decline.

This medication is dispensed strictly according to your doctor’s prescription and treatment plan.

What This Combination May Support

This compounded capsule may be prescribed for:

• Adrenal support
• Fatigue or low energy
• Brain fog or reduced mental clarity
• Low libido
• Perimenopause or menopause support
• Andropause (male hormone decline)
• Mood changes associated with hormonal imbalance
• Age-related hormone decline

Each patient’s needs are unique. Your doctor will determine whether this combination and strength is appropriate for you.

How It Works

Pregnenolone

Pregnenolone sits at the top of the hormone cascade. It supports the production of:

• Progesterone
• DHEA
• Cortisol
• Estrogen
• Testosterone

It may assist with:

• Cognitive clarity
• Stress resilience
• Mood stability
• Sleep regulation

DHEA

DHEA converts into androgenic and estrogenic hormones. It may support:

• Energy levels
• Libido
• Muscle tone
• Bone density
• Overall vitality

Together, this combination may support balanced hormone production under medical supervision.

Directions for Use

Take exactly as prescribed by your healthcare provider.

Typical guidance:

• Usually taken once daily
• Often recommended in the morning (to align with adrenal rhythms)
• Swallow capsule whole with water
• May be taken with food if sensitive stomach occurs

Do not adjust the dose without medical advice.

Important Safety Information

Before taking this medication, inform your doctor if you have:

• Hormone-sensitive cancers (breast, ovarian, uterine, prostate)
• Polycystic ovary syndrome (PCOS)
• Severe acne or androgen sensitivity
• Liver disease
• Cardiovascular disease
• Mood disorders
• Thyroid disorders

Because both DHEA and Pregnenolone influence hormone pathways, ongoing monitoring may be required.

Regular blood tests may be recommended to assess hormone levels and treatment response.

Possible Side Effects

Side effects vary depending on individual sensitivity and dosage.

Possible effects may include:

• Acne or oily skin
• Hair thinning (in women)
• Increased facial/body hair
• Mood changes
• Irritability
• Headache
• Sleep disturbance
• Changes in menstrual cycle
• Mild gastrointestinal discomfort

Higher doses may increase the likelihood of androgen-related side effects.

If you experience concerning symptoms, contact your healthcare provider.

Drug Interactions

This compounded medication may interact with:

• Hormone replacement therapy (HRT)
• Testosterone therapy
• Oral contraceptives
• Corticosteroids
• Thyroid medications
• Certain antidepressants
• Diabetes medications

Always inform your doctor and pharmacist of all medications and supplements you are taking.

Pregnancy & Breastfeeding

DHEA/Pregnenolone capsules are not recommended during pregnancy or breastfeeding unless specifically prescribed by a specialist.

If pregnancy occurs during treatment, seek medical advice immediately.

Storage Instructions

• Store below 25°C
• Keep away from heat and moisture
• Store in original container
• Keep out of reach of children
• Do not use after expiry date

Frequently Asked Questions

What is the difference between DHEA and Pregnenolone?

Pregnenolone is the precursor to DHEA and other hormones. DHEA sits further down the hormone pathway and converts into estrogen and testosterone.

Why are they prescribed together?

Some practitioners prescribe them together to support the entire hormone cascade rather than supplementing one hormone alone.

Is this safe long-term?

Long-term use requires medical supervision and periodic hormone testing to ensure safety and effectiveness.

Will this increase testosterone?

DHEA may convert into testosterone in some individuals, which is why monitoring is important.

When will I notice results?

Some patients report improvements in energy or clarity within a few weeks, but response varies individually.

Disclaimer

This information is intended for educational purposes only and does not replace professional medical advice. DHEA/Pregnenolone capsules should only be used under the supervision of a qualified healthcare professional.

For personalised advice regarding your prescription, speak with the pharmacists at Angel Pharmacy.