Metformin Hydrochloride (HCl)

Product Overview

Metformin Hydrochloride (HCl) 500mg is a prescription medication commonly used to help manage blood glucose levels.

It is most frequently prescribed for:

• Type 2 Diabetes
• Prediabetes
• Insulin resistance
• Polycystic Ovary Syndrome (PCOS) (off-label use)

Metformin belongs to a class of medicines called biguanides and is considered a first-line treatment for Type 2 Diabetes.

At Angel Pharmacy, Metformin 500mg tablets are supplied as commercially manufactured products in accordance with your doctor’s prescription.

How Metformin Works

Metformin helps control blood sugar levels by:

• Reducing glucose production in the liver
• Improving the body’s sensitivity to insulin
• Decreasing glucose absorption from the intestine

Unlike some diabetes medications, Metformin does not typically cause low blood sugar (hypoglycaemia) when used alone.

It may also support modest weight stabilisation in some patients.

What It Is Prescribed For

Type 2 Diabetes

Metformin is used to:

• Improve blood glucose control
• Lower HbA1c levels
• Reduce diabetes-related complications
• Support long-term metabolic health

It is often combined with lifestyle changes such as diet modification and exercise.

Prediabetes

In certain cases, Metformin may be prescribed to:

• Reduce progression to Type 2 Diabetes
• Improve insulin sensitivity
• Support metabolic risk reduction

Polycystic Ovary Syndrome (PCOS)

Metformin may be prescribed (off-label) to:

• Improve insulin resistance
• Support ovulatory function
• Help regulate menstrual cycles
• Assist with metabolic management in PCOS

Treatment for PCOS is supervised by a healthcare professional.

Directions for Use

Take exactly as prescribed by your doctor.

General guidance:

• Usually taken once or twice daily
• Best taken with food to reduce stomach upset
• Swallow tablets whole with water
• Take at the same time each day

Your doctor may start with a lower dose and gradually increase it to minimise gastrointestinal side effects.

Do not stop taking Metformin without medical advice.

Important Safety Information

Before starting Metformin, inform your doctor if you:

• Have kidney disease
• Have liver disease
• Have heart failure
• Drink excessive alcohol
• Are scheduled for surgery or imaging with contrast dye

Kidney function must be monitored before and during treatment.

Possible Side Effects

The most common side effects are gastrointestinal and often improve over time.

Common side effects:

• Nausea
• Diarrhoea
• Abdominal discomfort
• Bloating
• Loss of appetite

Rare but serious:

• Lactic acidosis (very rare but serious condition)

Seek urgent medical attention if you experience:

• Unusual muscle pain
• Severe weakness
• Difficulty breathing
• Dizziness
• Irregular heartbeat

Vitamin B12 Consideration

Long-term Metformin use may reduce Vitamin B12 levels in some individuals. Periodic monitoring may be recommended, especially if you experience fatigue, numbness, or tingling.

Drug Interactions

Metformin may interact with:

• Contrast dyes used in imaging procedures
• Certain blood pressure medications
• Diuretics
• Other diabetes medications

Always inform your healthcare provider about all medications and supplements you are taking.

Pregnancy & Breastfeeding

Metformin may be used during pregnancy in certain cases under medical supervision. Your doctor will determine suitability based on your individual circumstances.

If breastfeeding, discuss risks and benefits with your healthcare provider.

Storage Instructions

• Store below 25°C
• Keep in original packaging
• Protect from moisture
• Keep out of reach of children
• Do not use after expiry date

Frequently Asked Questions

Does Metformin cause low blood sugar?

When taken alone, it rarely causes hypoglycaemia. However, risk increases if combined with other diabetes medications.

Can Metformin help with weight loss?

Some people experience mild weight reduction or weight stabilisation, but it is not primarily a weight-loss medication.

How long does Metformin take to work?

Blood glucose levels may begin improving within days, but full HbA1c improvement may take 2–3 months.

Why does Metformin upset my stomach?

Gastrointestinal side effects are common at the start of treatment. Taking it with food and gradual dose increases usually help.

Do I need regular blood tests?

Yes. Kidney function, blood glucose levels, and sometimes Vitamin B12 levels should be monitored periodically.

Disclaimer

This information is provided for educational purposes only and does not replace professional medical advice. Metformin should only be used under the supervision of a qualified healthcare provider.

For personalised advice regarding your prescription, speak with the pharmacists at Angel Pharmacy.